Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome.

Transgenic mice which carry hybrid p53 promoter-chloramphenicol acetyltransferase (CAT) transgenes were found to express CAT enzymatic activity predominantly in the testes. Endogenous levels of p53 mRNA and protein were lower than in the nontransgenic control mice. The various p53 promoter-CAT trans...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rotter, V, Schwartz, D, Almon, E, Goldfinger, N, Kapon, A, Meshorer, A, Donehower, L A, Levine, A J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47504/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8415656/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.19.9075
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