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Mitochondrial DNA damage induced autophagy, cell death, and disease

Mammalian mitochondria contain multiple small genomes. While these organelles have efficient base excision removal of oxidative DNA lesions and alkylation damage, many DNA repair systems that work on nuclear DNA damage are not active in mitochondria. What is the fate of DNA damage in the mitochondri...

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Bibliografiska uppgifter
I publikationen:Front Biosci (Landmark Ed)
Huvudupphovsmän: Van Houten, Bennett, Hunter, Senyene E., Meyer, Joel N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750375/
https://ncbi.nlm.nih.gov/pubmed/26709760
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