New insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases

Glyoxylate accumulation within cells is highly toxic. In humans, it is associated with hyperoxaluria type 2 (PH2) leading to renal failure. The glyoxylate content within cells is regulated by the NADPH/NADH dependent glyoxylate/hydroxypyruvate reductases (GRHPR). These are highly conserved enzymes w...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Lassalle, Louise, Engilberge, Sylvain, Madern, Dominique, Vauclare, Pierre, Franzetti, Bruno, Girard, Eric
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749974/
https://ncbi.nlm.nih.gov/pubmed/26865263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20629
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