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New insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases
Glyoxylate accumulation within cells is highly toxic. In humans, it is associated with hyperoxaluria type 2 (PH2) leading to renal failure. The glyoxylate content within cells is regulated by the NADPH/NADH dependent glyoxylate/hydroxypyruvate reductases (GRHPR). These are highly conserved enzymes w...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4749974/ https://ncbi.nlm.nih.gov/pubmed/26865263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20629 |
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