Simultaneous Pharmacokinetic Modeling of Gentamicin, Tobramycin and Vancomycin Clearance from Neonates to Adults: Towards a Semi-physiological Function for Maturation in Glomerular Filtration

PURPOSE: Since glomerular filtration rate (GFR) is responsible for the elimination of a large number of water-soluble drugs, the aim of this study was to develop a semi-physiological function for GFR maturation from neonates to adults. METHODS: In the pharmacokinetic analysis (NONMEM VI) based on da...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: De Cock, Roosmarijn F. W., Allegaert, Karel, Brussee, Janneke M., Sherwin, Catherine M. T., Mulla, Hussain, de Hoog, Matthijs, van den Anker, Johannes N., Danhof, Meindert, Knibbe, Catherijne A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749758/
https://ncbi.nlm.nih.gov/pubmed/24789450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-014-1361-z
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