8-Hydroxyquinoline-Based Inhibitors of the Rce1 Protease Disrupt Ras Membrane Localization in Human Cells

Ras converting enzyme 1 (Rce1) is an endoprotease that catalyzes processing of the C-terminus of Ras protein by removing -aaX from the CaaX motif. The activity of Rce1 is crucial for proper localization of Ras to the plasma membrane where it functions. Ras is responsible for transmitting signals rel...

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Publicado no:Bioorg Med Chem
Main Authors: Mohammed, Idrees, Hampton, Shahienaz E., Ashall, Louise, Hildebrandt, Emily R., Kutlik, Robert A., Manandhar, Surya P., Floyd, Brandon J., Smith, Haley E., Dozier, Jonathan K., Distefano, Mark D., Schmidt, Walter K., Dore, Timothy M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749511/
https://ncbi.nlm.nih.gov/pubmed/26706114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.11.043
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