[(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer

The nuclear enzyme PARP1 plays a central role in sensing DNA damage and facilitating repair. Tumors with BRCA1/2 mutations are highly dependent on PARP1 as an alternative mechanism for DNA repair, and PARP inhibitors generate synthetic lethality in tumors with BRCA mutations, resulting in cell cycle...

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Bibliografske podrobnosti
izdano v:Am J Nucl Med Mol Imaging
Main Authors: Edmonds, Christine E, Makvandi, Mehran, Lieberman, Brian P, Xu, Kuiying, Zeng, Chenbo, Li, Shihong, Hou, Catherine, Lee, Hsiaoju, Greenberg, Roger A, Mankoff, David A, Mach, Robert H
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2016
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749508/
https://ncbi.nlm.nih.gov/pubmed/27069769
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