White matter lesion progression: A genome-wide search for genetic influences

BACKGROUND AND PURPOSE: White matter lesion (WML) progression on magnetic resonance imaging (MRI) is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants a...

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Pubblicato in:Stroke
Autori principali: Hofer, Edith, Cavalieri, Margherita, Bis, Joshua C, DeCarli, Charles, Fornage, Myriam, Sigurdsson, Sigurdur, Srikanth, Velandai, Trompet, Stella, Verhaaren, Benjamin FJ, Wolf, Christiane, Yang, Qiong, Adams, Hieab HH, Amouyel, Philippe, Beiser, Alexa, Buckley, Brendan M, Callisaya, Michele, Chauhan, Ganesh, de Craen, Anton JM, Dufouil, Carole, van Duijn, Cornelia M, Ford, Ian, Freudenberger, Paul, Gottesman, Rebecca F, Gudnason, Vilmundur, Heiss, Gerardo, Hofman, Albert, Lumley, Thomas, Martinez, Oliver, Mazoyer, Bernard, Moran, Chris, Niessen, Wiro J., Phan, Thanh, Psaty, Bruce M, Satizabal, Claudia L, Sattar, Naveed, Schilling, Sabrina, Shibata, Dean K, Slagboom, P Eline, Smith, Albert, Stott, David J, Taylor, Kent D, Thomson, Russell, Töglhofer, Anna M, Tzourio, Christophe, van Buchem, Mark, Wang, Jing, Westendorp, Rudi GJ, Windham, B Gwen, Vernooij, Meike W, Zijdenbos, Alex, Beare, Richard, Debette, Stéphanie, Ikram, M Arfan, Jukema, J Wouter, Launer, Lenore J, Longstreth, W T, Mosley, Thomas H, Seshadri, Sudha, Schmidt, Helena, Schmidt, Reinhold
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749149/
https://ncbi.nlm.nih.gov/pubmed/26451028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.115.009252
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