An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis

Human epidermal growth factor receptor 2 (HER2) is upregulated in a subset of human breast cancers. However, the cancer cells often quickly develop an adaptive response to HER2 kinase inhibitors. We found that an epigenetic pathway involving MLL2 is crucial for growth of HER2(+) cells and MLL2 reduc...

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Bibliografske podrobnosti
izdano v:Cancer Cell
Main Authors: Matkar, Smita, Sharma, Paras, Gao, Shubin, Gurung, Buddha, Katona, Bryson W, Liao, Jennifer, Muhammad, Abdul Bari, Kong, Xiang-Cheng, Wang, Lei, Jin, Guanghui, Dang, Chi, Hua, Xianxin
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748715/
https://ncbi.nlm.nih.gov/pubmed/26461093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.09.005
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