An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis

Human epidermal growth factor receptor 2 (HER2) is upregulated in a subset of human breast cancers. However, the cancer cells often quickly develop an adaptive response to HER2 kinase inhibitors. We found that an epigenetic pathway involving MLL2 is crucial for growth of HER2(+) cells and MLL2 reduc...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Matkar, Smita, Sharma, Paras, Gao, Shubin, Gurung, Buddha, Katona, Bryson W, Liao, Jennifer, Muhammad, Abdul Bari, Kong, Xiang-Cheng, Wang, Lei, Jin, Guanghui, Dang, Chi, Hua, Xianxin
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748715/
https://ncbi.nlm.nih.gov/pubmed/26461093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.09.005
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