Metformin improves the angiogenic potential of human CD34(+) cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM). To identify the most effective treatment for CVD, it is paramount to understand the mechanism behind cardioprotective therapies. Although metformin has been shown to redu...

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Bibliografiske detaljer
Udgivet i:Cardiovasc Diabetol
Main Authors: Bakhashab, Sherin, Ahmed, Fahad W., Schulten, Hans-Juergen, Bashir, Ayat, Karim, Sajjad, Al-Malki, Abdulrahman L., Gari, Mamdooh A., Abuzenadah, Adel M., Chaudhary, Adeel G., Alqahtani, Mohammed H., Lary, Sahira, Ahmed, Farid, Weaver, Jolanta U.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748498/
https://ncbi.nlm.nih.gov/pubmed/26861446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-016-0344-2
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