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Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia

Cardiovascular disease is the leading cause of morbidity/mortality worldwide. Metformin is the first therapy offering cardioprotection in type 2 diabetes and non-diabetic animals with unknown mechanism. We have shown that metformin improves angiogenesis via affecting expression of growth factors/ang...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Bakhashab, Sherin, Ahmed, Farid, Schulten, Hans-Juergen, Ahmed, Fahad W., Glanville, Michael, Al-Qahtani, Mohammed H., Weaver, Jolanta U.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796238/
https://ncbi.nlm.nih.gov/pubmed/29351188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19010293
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