The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN

We have reported the antidepressant effects of both metabotropic glutamate 2/3 (mGlu2/3) receptor antagonists and ketamine in several animal models, and proposed that serotonergic (5-HTergic) transmission is involved in these actions. Given that the projections from the medial prefrontal cortex (mPF...

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Veröffentlicht in:Neuropsychopharmacology
Hauptverfasser: Fukumoto, Kenichi, Iijima, Michihiko, Chaki, Shigeyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748429/
https://ncbi.nlm.nih.gov/pubmed/26245499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.233
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