The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking and Relapse with Low Side-Effect Profile

Preclinical studies revealed contribution of N-methyl-D-aspartate receptors (NMDARs) to a variety of neuropsychiatric diseases including alcoholism, but development of NMDAR antagonists for therapeutic use has been a challenge, in part due to severe side effects. One of the key intracellular events...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Vengeliene, Valentina, Moeller, Achim, Meinhardt, Marcus W, Beardsley, Patrick M, Sommer, Wolfgang H, Spanagel, Rainer, Bespalov, Anton
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748423/
https://ncbi.nlm.nih.gov/pubmed/26216521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.225
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