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The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin
Anthracyclines such as daunorubicin are anticancer agents that are transported into cells, and exert cytotoxicity by blocking DNA metabolism. Although there is evidence for active uptake of anthracyclines into cells, the specific transporter involved in this process has not been identified. Using th...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4748219/ https://ncbi.nlm.nih.gov/pubmed/26861753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20508 |
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