Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H(3) receptors

BACKGROUND: Histamine H(3) receptor (H(3)R) is a potential therapeutic target of sleep- and cognition-related disorders. The purpose of the present study is to develop a novel positron emission tomography (PET) ligand for H(3)Rs from dihydroquinolinone derivatives, which we previously found to have...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Koga, Kazumi, Maeda, Jun, Tokunaga, Masaki, Hanyu, Masayuki, Kawamura, Kazunori, Ohmichi, Mari, Nakamura, Toshio, Nagai, Yuji, Seki, Chie, Kimura, Yasuyuki, Minamimoto, Takafumi, Zhang, Ming-Rong, Fukumura, Toshimitsu, Suhara, Tetsuya, Higuchi, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747952/
https://ncbi.nlm.nih.gov/pubmed/26860293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-016-0170-2
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