2-DEOXY-GLUCOSE DOWN REGULATES ENDOTHELIAL AKT AND ERK VIA INTERFERENCE WITH N-LINKED GLYCOSYLATION, INDUCTION OF ENDOPLASMIC RETICULUM STRESS AND GSK-3β ACTIVATION

Interference with endothelial cell metabolism is a promising, yet unexploited strategy for angiogenesis inhibition. We reported that the glucose analog, 2-deoxy-D-Glucose (2-DG) inhibits angiogenesis at significantly lower concentrations than those required for tumor cytotoxicity. Here, we found tha...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Kovács, Krisztina, Decatur, Christina, Toro, Marcela, Pham, Dien G., Liu, Huaping, Jing, Yuqi, Murray, Timothy G., Lampidis, Theodore J., Merchan, Jaime R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747846/
https://ncbi.nlm.nih.gov/pubmed/26637370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0315
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