Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes

Detection of somatic mutations in HLA genes using whole-exome sequencing (WES) is hampered by the high polymorphism of the HLA loci, which prevents alignment of sequencing reads to the human reference genome. We describe a computational pipeline that enables accurate inference of germline alleles of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Shukla, Sachet A., Rooney, Michael S., Rajasagi, Mohini, Tiao, Grace, Dixon, Philip M., Lawrence, Michael S., Stevens, Jonathan, Lane, William J., Dellagatta, Jamie L., Steelman, Scott, Sougnez, Carrie, Cibulskis, Kristian, Kiezun, Adam, Brusic, Vladimir, Wu, Catherine J., Getz, Gad
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747795/
https://ncbi.nlm.nih.gov/pubmed/26372948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3344
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados