Synthetic gene network restoring endogenous pituitary–thyroid feedback control in experimental Graves’ disease

Graves’ disease is an autoimmune disorder that causes hyperthyroidism because of autoantibodies that bind to the thyroid-stimulating hormone receptor (TSHR) on the thyroid gland, triggering thyroid hormone release. The physiological control of thyroid hormone homeostasis by the feedback loops involv...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Saxena, Pratik, Charpin-El Hamri, Ghislaine, Folcher, Marc, Zulewski, Henryk, Fussenegger, Martin
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747754/
https://ncbi.nlm.nih.gov/pubmed/26787873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514383113
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