Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization

The extracellular matrix polysaccharide hyaluronan (HA) accumulates at sites of autoimmune inflammation, including white matter lesions in multiple sclerosis (MS), but its functional importance in pathogenesis is unclear. We have evaluated the impact of 4-methylumbelliferone (4-MU), an oral inhibito...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kuipers, Hedwich F., Rieck, Mary, Gurevich, Irina, Nagy, Nadine, Butte, Manish J., Negrin, Robert S., Wight, Thomas N., Steinman, Lawrence, Bollyky, Paul L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747722/
https://ncbi.nlm.nih.gov/pubmed/26787861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525086113
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