Humanized Mouse Model of Ebola Virus Disease Mimics the Immune Responses in Human Disease

Animal models recapitulating human Ebola virus disease (EVD) are critical for insights into virus pathogenesis. Ebola virus (EBOV) isolates derived directly from human specimens do not, without adaptation, cause disease in immunocompetent adult rodents. Here, we describe EVD in mice engrafted with h...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Bird, Brian H., Spengler, Jessica R., Chakrabarti, Ayan K., Khristova, Marina L., Sealy, Tara K., Coleman-McCray, JoAnn D., Martin, Brock E., Dodd, Kimberly A., Goldsmith, Cynthia S., Sanders, Jeanine, Zaki, Sherif R., Nichol, Stuart T., Spiropoulou, Christina F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747627/
https://ncbi.nlm.nih.gov/pubmed/26582961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv538
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