Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells

Flavokawain C (FKC) is a naturally occurring chalcone which can be found in Kava (Piper methysticum Forst) root. The present study evaluated the effect of FKC on the growth of various human cancer cell lines and the underlying associated mechanisms. FKC showed higher cytotoxic activity against HCT 1...

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Bibliographic Details
Published in:PLoS One
Main Authors: Phang, Chung-Weng, Karsani, Saiful Anuar, Sethi, Gautam, Abd Malek, Sri Nurestri
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747580/
https://ncbi.nlm.nih.gov/pubmed/26859847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148775
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