Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-β-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts

Transforming growth factor-β (TGF-β) is central during the pathogenesis of pulmonary fibrosis, in which the plasminogen activator inhibitor-1 (PAI-1) also has an established role. TGF-β is also known to be the strongest inducer of PAI-1. To investigate the link between PAI-1 and TGF-β in fibrotic pr...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Omori, Keitaro, Hattori, Noboru, Senoo, Tadashi, Takayama, Yusuke, Masuda, Takeshi, Nakashima, Taku, Iwamoto, Hiroshi, Fujitaka, Kazunori, Hamada, Hironobu, Kohno, Nobuoki
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747467/
https://ncbi.nlm.nih.gov/pubmed/26859294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148969
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