Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

Pancreatic β-cells normally produce adequate insulin to control glucose homeostasis, but in obesity-related diabetes, there is a presumed deficit in insulin production and secretory capacity. In this study, insulin production was assessed directly in obese diabetic mouse models, and proinsulin biosy...

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Détails bibliographiques
Publié dans:Diabetes
Auteurs principaux: Alarcon, Cristina, Boland, Brandon B., Uchizono, Yuji, Moore, Patrick C., Peterson, Bryan, Rajan, Suryalekha, Rhodes, Olivia S., Noske, Andrew B., Haataja, Leena, Arvan, Peter, Marsh, Bradly J., Austin, Jotham, Rhodes, Christopher J.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2016
Sujets:
Islet Studies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747460/
https://ncbi.nlm.nih.gov/pubmed/26307586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0792
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