Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants

Large genome-wide association studies of glycemic traits have identified genetics variants that are associated with insulin resistance (IR) in the general population. It is unknown whether people with genetic enrichment for these IR variants respond differently to interventions that aim to improve i...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Hivert, Marie-France, Christophi, Costas A., Franks, Paul W., Jablonski, Kathleen A., Ehrmann, David A., Kahn, Steven E., Horton, Edward S., Pollin, Toni I., Mather, Kieren J., Perreault, Leigh, Barrett-Connor, Elizabeth, Knowler, William C., Florez, Jose C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2016
Assuntos:
Genetics/Genomes/Proteomics/Metabolomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747453/
https://ncbi.nlm.nih.gov/pubmed/26525880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0950
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