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In-membrane chemical modification (IMCM) for site-specific chromophore labeling of GPCRs

We present “in-membrane chemical modification” (IMCM) for obtaining selective chromophore labeling of intracellular surface cysteines in G protein-coupled receptors (GPCRs) with minimal mutagenesis. Practical use of IMCM is illustrated with site-specific introduction of chromophores for NMR and fluo...

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Publicado en:Angew Chem Int Ed Engl
Autores principales: Sušac, Lukas, O’Connor, Casey, Stevens, Raymond C., Wüthrich, Kurt
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747426/
https://ncbi.nlm.nih.gov/pubmed/26545333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508506
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