Doxycycline reverses epithelial-to-mesenchymal transition and suppresses the proliferation and metastasis of lung cancer cells

The gelatinase inhibitor doxycycline is the prototypical antitumor antibiotic. We investigated the effects of doxycycline on the migration, invasion, and metastasis of human lung cancer cell lines and in a mouse model. We also measured the effect of doxycycline on the transcription of epithelial-mes...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Qin, Yuan, Zhang, Qiang, Lee, Shan, Zhong, Wei-long, Liu, Yan-rong, Liu, Hui-juan, Zhao, Dong, Chen, Shuang, Xiao, Ting, Meng, Jing, Jing, Xue-shuang, Wang, Jing, Sun, Bo, Dai, Ting-ting, Yang, Cheng, Sun, Tao, Zhou, Hong-gang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747360/
https://ncbi.nlm.nih.gov/pubmed/26512779
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