Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription

The estrogen receptor α (ERα) controls cell proliferation and tumorigenesis by recruiting various cofactors to estrogen response elements (EREs) to control gene transcription. A deeper understanding of these transcriptional mechanisms may uncover therapeutic targets for ERα-dependent cancers. We sho...

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Vydáno v:Cell Rep
Hlavní autoři: Nagarajan, Sankari, Hossan, Tareq, Alawi, Malik, Najafova, Zeynab, Indenbirken, Daniela, Bedi, Upasana, Taipaleenmäki, Hanna, Ben-Batalla, Isabel, Scheller, Marina, Loges, Sonja, Knapp, Stefan, Hesse, Eric, Chiang, Cheng-Ming, Grundhoff, Adam, Johnsen, Steven A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747248/
https://ncbi.nlm.nih.gov/pubmed/25017071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.016
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