Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS)

About 85% of GISTs are associated with KIT and PDGFRα gene mutations, which predict response to tyrosine kinase inhibitors. Although the outcomes in patients affected by GIST have dramatically improved, tumor progression control still remains a challenge. The aim of this study is the genomic charact...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Saponara, Maristella, Urbini, Milena, Astolfi, Annalisa, Indio, Valentina, Ercolani, Giorgio, Del Gaudio, Massimo, Santini, Donatella, Pirini, Maria Giulia, Fiorentino, Michelangelo, Nannini, Margherita, Lolli, Cristian, Mandrioli, Anna, Gatto, Lidia, Brandi, Giovanni, Biasco, Guido, Pinna, Antonio Daniele, Pantaleo, Maria Abbondanza
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747222/
https://ncbi.nlm.nih.gov/pubmed/26544626
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