Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS)

About 85% of GISTs are associated with KIT and PDGFRα gene mutations, which predict response to tyrosine kinase inhibitors. Although the outcomes in patients affected by GIST have dramatically improved, tumor progression control still remains a challenge. The aim of this study is the genomic charact...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Saponara, Maristella, Urbini, Milena, Astolfi, Annalisa, Indio, Valentina, Ercolani, Giorgio, Del Gaudio, Massimo, Santini, Donatella, Pirini, Maria Giulia, Fiorentino, Michelangelo, Nannini, Margherita, Lolli, Cristian, Mandrioli, Anna, Gatto, Lidia, Brandi, Giovanni, Biasco, Guido, Pinna, Antonio Daniele, Pantaleo, Maria Abbondanza
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2015
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747222/
https://ncbi.nlm.nih.gov/pubmed/26544626
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