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Assessing the therapeutic efficacy of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig

Given the rapid onset of symptoms from intoxication by organophosphate (OP) compounds, a quick-acting, efficacious therapeutic regimen is needed. A primary component of anti-OP therapy is an oxime reactivator to rescue OP-inhibited acetylcholinesterases. Male guinea pigs, clipped of hair, received n...

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Bibliographische Detailangaben
Veröffentlicht in:J Toxicol Sci
Hauptverfasser: Snider, Thomas H., Wilhelm, Christina M., Babin, Michael C., Platoff, Gennady E., Yeung, David T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747113/
https://ncbi.nlm.nih.gov/pubmed/26558457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2131/jts.40.759
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