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The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures

BACKGROUND: BAF312 (Siponimod) is a dual agonist at the sphingosine-1 phosphate receptors, S1PR1 and S1PR5. This drug is currently undergoing clinical trials for the treatment of secondary progressive multiple sclerosis (MS). Here, we investigated the effects of BAF312 on isolated astrocyte and micr...

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Dades bibliogràfiques
Publicat a:J Neuroinflammation
Autors principals: O’Sullivan, Catherine, Schubart, Anna, Mir, Anis K., Dev, Kumlesh K.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746808/
https://ncbi.nlm.nih.gov/pubmed/26856814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0494-x
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