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Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation

BACKGROUND: The insulin-like growth factor (IGF) system impacts cellular development by regulating proliferation, differentiation, and apoptosis, and is an attractive therapeutic target in cancer. The IGF system is complex, with two ligands (IGF1, IGF2), two receptors (IGF1R, IGF2R), and at least si...

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Publicat a:BMC Syst Biol
Autors principals: Tian, Dan, Mitchell, Isaiah, Kreeger, Pamela K.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746774/
https://ncbi.nlm.nih.gov/pubmed/26861122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-016-0263-6
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