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Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation

BACKGROUND: The insulin-like growth factor (IGF) system impacts cellular development by regulating proliferation, differentiation, and apoptosis, and is an attractive therapeutic target in cancer. The IGF system is complex, with two ligands (IGF1, IGF2), two receptors (IGF1R, IGF2R), and at least si...

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Detaylı Bibliyografya
Yayımlandı:BMC Syst Biol
Asıl Yazarlar: Tian, Dan, Mitchell, Isaiah, Kreeger, Pamela K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746774/
https://ncbi.nlm.nih.gov/pubmed/26861122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-016-0263-6
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