Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

Abnormal regional increases in DNA methylation, which have potential for causing gene inactivation and chromosomal instability, are consistently found in immortalized and tumorigenic cells. Increased DNA methyltransferase activity, which is also a characteristic of such cells, is a candidate to medi...

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Autori principali: Wu, J, Issa, J P, Herman, J, Bassett, D E, Nelkin, B D, Baylin, S B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1993
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC47466/
https://ncbi.nlm.nih.gov/pubmed/8415627
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