Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

Abnormal regional increases in DNA methylation, which have potential for causing gene inactivation and chromosomal instability, are consistently found in immortalized and tumorigenic cells. Increased DNA methyltransferase activity, which is also a characteristic of such cells, is a candidate to medi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wu, J, Issa, J P, Herman, J, Bassett, D E, Nelkin, B D, Baylin, S B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47466/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8415627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.19.8891
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