Impact of a large deletion in the neuraminidase protein identified in a laninamivir‐selected influenza A/Brisbane/10/2007 (H3N2) variant on viral fitness in vitro and in ferrets

Viral fitness of a laninamivir‐selected influenza A/Brisbane/10/2007‐like (H3N2) isolate (LRVp9) containing a 237‐amino acid neuraminidase deletion and a P194L hemagglutinin mutation was evaluated in vitro and in ferrets. LRVp9 and the wild‐type (WT) virus showed comparable replication kinetics in M...

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Detalhes bibliográficos
Publicado no:Influenza Other Respir Viruses
Main Authors: Ann, Julie, Abed, Yacine, Beaulieu, Edith, Bouhy, Xavier, Joly, Marie‐Hélène, Dubé, Karen, Carbonneau, Julie, Hamelin, Marie‐Eve, Mallett, Corey, Boivin, Guy
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Short Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746560/
https://ncbi.nlm.nih.gov/pubmed/26526406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/irv.12356
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