Molecular Mechanisms and Potential Clinical Applications of Campylobacter jejuni Cytolethal Distending Toxin

Cytolethal distending toxin (CDT), a genotoxin produced by Campylobacter jejuni, is composed of three subunits: CdtA, CdtB, and CdtC. CdtB is a DNase that causes DNA double-strand breaks (DSB) in the nucleus resulting in cell cycle arrest at the G2/M stage and apoptosis. CdtA and CdtC bind to choles...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Lai, Cheng-Kuo, Chen, Yu-An, Lin, Chun-Jung, Lin, Hwai-Jeng, Kao, Min-Chuan, Huang, Mei-Zi, Lin, Yu-Hsin, Chiang-Ni, Chuan, Chen, Chih-Jung, Lo, U-Ging, Lin, Li-Chiung, Lin, Ho, Hsieh, Jer-Tsong, Lai, Chih-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746238/
https://ncbi.nlm.nih.gov/pubmed/26904508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2016.00009
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