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Effect of reducing the paediatric stavudine dose by half: a physiologically-based pharmacokinetic model

Owing to significant dose-related toxicity, the adult stavudine dose was reduced in 2007. The paediatric dose, however, has not been reduced. Although the intended paediatric dose is 1 mg/kg twice daily (b.i.d.), the current weight-band dosing approach results in a mean actual dose of 1.23 ± 0.47 mg...

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Podrobná bibliografie
Vydáno v:Int J Antimicrob Agents
Hlavní autoři: Sy, Sherwin K.B., Malmberg, Ruben, Matsushima, Aoi, Asin-Prieto, Eduardo, Rosenkranz, Bernd, Cotton, Mark F., Derendorf, Hartmut, Innes, Steve
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746231/
https://ncbi.nlm.nih.gov/pubmed/25697412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijantimicag.2014.12.016
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