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Effect of reducing the paediatric stavudine dose by half: a physiologically-based pharmacokinetic model
Owing to significant dose-related toxicity, the adult stavudine dose was reduced in 2007. The paediatric dose, however, has not been reduced. Although the intended paediatric dose is 1 mg/kg twice daily (b.i.d.), the current weight-band dosing approach results in a mean actual dose of 1.23 ± 0.47 mg...
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| Publicado no: | Int J Antimicrob Agents |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4746231/ https://ncbi.nlm.nih.gov/pubmed/25697412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijantimicag.2014.12.016 |
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