Evaluation of the Therapeutic Potential of Anti-TLR4-Antibody MTS510 in Experimental Stroke and Significance of Different Routes of Application

Toll-like receptors (TLRs) are central sensors for the inflammatory response in ischemia-reperfusion injury. We therefore investigated whether TLR4 inhibition could be used to treat stroke in a standard model of focal cerebral ischemia. Anti-TLR4/MD2-antibody (mAb clone MTS510) blocked TLR4-induced...

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Publicat a:PLoS One
Autors principals: Andresen, Lena, Theodorou, Konstantina, Grünewald, Sarah, Czech-Zechmeister, Bozena, Könnecke, Birte, Lühder, Fred, Trendelenburg, George
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746129/
https://ncbi.nlm.nih.gov/pubmed/26849209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148428
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