Picoliter-Droplet Digital Polymerase Chain Reaction-Based Analysis of Cell-Free Plasma DNA to Assess EGFR Mutations in Lung Adenocarcinoma That Confer Resistance to Tyrosine-Kinase Inhibitors

PURPOSE. The objective of this study was to evaluate the utility of analyzing cell-free plasma DNA (cfDNA) by picoliter-droplet digital polymerase chain reaction (ddPCR) to detect EGFR mutations that confer resistance to tyrosine-kinase inhibitors (TKIs) used for treatment of lung adenocarcinoma (LA...

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Veröffentlicht in:Oncologist
Hauptverfasser: Seki, Yoshitaka, Fujiwara, Yutaka, Kohno, Takashi, Takai, Erina, Sunami, Kuniko, Goto, Yasushi, Horinouchi, Hidehito, Kanda, Shintaro, Nokihara, Hiroshi, Watanabe, Shun-ichi, Ichikawa, Hitoshi, Yamamoto, Noboru, Kuwano, Kazuyoshi, Ohe, Yuichiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: AlphaMed Press 2016
Schlagworte:
Cancer Diagnostics and Molecular Pathology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746084/
https://ncbi.nlm.nih.gov/pubmed/26768482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2015-0288
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