SYNONYMOUS CODONS DIRECT CO-TRANSLATIONAL FOLDING TOWARDS DIFFERENT PROTEIN CONFORMATIONS

In all genomes, most amino acids are encoded by more than one codon. Synonymous codons can modulate protein production and folding, but the mechanism connecting codon usage to protein homeostasis is not known. Here we show that synonymous codon variants in the gene encoding gamma-B crystallin, a mam...

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Publicado en:Mol Cell
Main Authors: Buhr, Florian, Jha, Sujata, Thommen, Michael, Mittelstaet, Joerg, Kutz, Felicitas, Schwalbe, Harald, Rodnina, Marina V., Komar, Anton A.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745992/
https://ncbi.nlm.nih.gov/pubmed/26849192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.01.008
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