SYNONYMOUS CODONS DIRECT CO-TRANSLATIONAL FOLDING TOWARDS DIFFERENT PROTEIN CONFORMATIONS

In all genomes, most amino acids are encoded by more than one codon. Synonymous codons can modulate protein production and folding, but the mechanism connecting codon usage to protein homeostasis is not known. Here we show that synonymous codon variants in the gene encoding gamma-B crystallin, a mam...

Full description

Saved in:
Bibliographic Details
Published in:Mol Cell
Main Authors: Buhr, Florian, Jha, Sujata, Thommen, Michael, Mittelstaet, Joerg, Kutz, Felicitas, Schwalbe, Harald, Rodnina, Marina V., Komar, Anton A.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745992/
https://ncbi.nlm.nih.gov/pubmed/26849192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.01.008
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items