Localized TRPA1 channel Ca(2+) signals stimulated by reactive oxygen species promote cerebral artery dilation

Reactive oxygen species (ROS) can have divergent effects in cerebral and peripheral circulations. We found that Ca(2+)-permeable transient receptor potential ankyrin 1 (TRPA1) channels were present and colocalized with NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase 2 (NO...

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Vydáno v:Sci Signal
Hlavní autoři: Sullivan, Michelle N., Gonzales, Albert L., Pires, Paulo W., Bruhl, Allison, Leo, M. Dennis, Li, Wencheng, Oulidi, Agathe, Boop, Frederick A., Feng, Yumei, Jaggar, Jonathan H., Welsh, Donald G., Earley, Scott
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745898/
https://ncbi.nlm.nih.gov/pubmed/25564678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005659
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