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Localized TRPA1 channel Ca(2+) signals stimulated by reactive oxygen species promote cerebral artery dilation

Reactive oxygen species (ROS) can have divergent effects in cerebral and peripheral circulations. We found that Ca(2+)-permeable transient receptor potential ankyrin 1 (TRPA1) channels were present and colocalized with NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase 2 (NO...

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Pubblicato in:Sci Signal
Autori principali: Sullivan, Michelle N., Gonzales, Albert L., Pires, Paulo W., Bruhl, Allison, Leo, M. Dennis, Li, Wencheng, Oulidi, Agathe, Boop, Frederick A., Feng, Yumei, Jaggar, Jonathan H., Welsh, Donald G., Earley, Scott
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745898/
https://ncbi.nlm.nih.gov/pubmed/25564678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005659
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