NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3

DDX3X (DDX3), a human RNA helicase, is over expressed in multiple breast cancer cell lines and its expression levels are directly correlated to cellular aggressiveness. NZ51, a ring-expanded nucleoside analogue (REN) has been reported to inhibit the ATP dependent helicase activity of DDX3. Molecular...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Xie, Min, Vesuna, Farhad, Botlagunta, Mahendran, Bol, Guus Martinus, Irving, Ashley, Bergman, Yehudit, Hosmane, Ramachandra S., Kato, Yoshinori, Winnard, Paul T., Raman, Venu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745771/
https://ncbi.nlm.nih.gov/pubmed/26337079
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