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Capsular Polysaccharide (CPS) Release by Serotype 3 Pneumococcal Strains Reduces the Protective Effect of Anti-Type 3 CPS Antibodies

The efficacy of the serotype 3 (ST3) pneumococcal conjugate vaccine (PCV) remains unclear. While the synthesis of capsular polysaccharide (CPS) of most serotypes is wzy dependent, the strains of two serotypes, 3 and 37, synthesize CPS by the synthase-dependent pathway, resulting in a polysaccharide...

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Pubblicato in:Clin Vaccine Immunol
Autori principali: Choi, Eun Hwa, Zhang, Fan, Lu, Ying-Jie, Malley, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744920/
https://ncbi.nlm.nih.gov/pubmed/26677201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00591-15
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