Formation of the Δ(18,19) Double Bond and Bis(spiroacetal) in Salinomycin Is Atypically Catalyzed by SlnM, a Methyltransferase‐like Enzyme

Salinomycin is a widely used polyether coccidiostat and was recently found to have antitumor activities. However, the mechanism of its biosynthesis remained largely speculative until now. Reported herein is the identification of an unprecedented function of SlnM, homologous to O‐methyltransferases,...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Angew Chem Int Ed Engl
Egile Nagusiak: Jiang, Chunyan, Qi, Zhen, Kang, Qianjin, Liu, Jing, Jiang, Ming, Bai, Linquan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: WILEY‐VCH Verlag 2015
Gaiak:
Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744726/
https://ncbi.nlm.nih.gov/pubmed/26096919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201503561
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