Pharmacokinetic and Pharmacodynamic Comparison of Once‐Daily Efavirenz (400 mg vs. 600 mg) in Treatment‐Naïve HIV‐Infected Patients: Results of the ENCORE1 Study

Daily efavirenz 400 mg (EFV400) was virologically noninferior to 600 mg (EFV600) at 48 weeks in treatment‐naïve patients. We evaluated EFV400 and EFV600 pharmacokinetics (NONMEM v. 7.2), assessing patient demographics and genetic polymorphisms (CYP2B6, CYP2A6, CYP3A4, NR1I3) as covariates and explor...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Dickinson, L, Amin, J, Else, L, Boffito, M, Egan, D, Owen, A, Khoo, S, Back, D, Orrell, C, Clarke, A, Losso, M, Phanuphak, P, Carey, D, Cooper, DA, Emery, S
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744681/
https://ncbi.nlm.nih.gov/pubmed/26044067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.156
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