Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice

AIMS/HYPOTHESIS: Reprogramming of pancreatic exocrine to insulin-producing cells by viral delivery of the genes encoding transcription factors neurogenin-3 (Ngn3), pancreas/duodenum homeobox protein 1 (Pdx1) and MafA is an efficient method for reversing diabetes in murine models. The variables that...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Cavelti-Weder, Claudia, Li, Weida, Zumsteg, Adrian, Stemann-Andersen, Marianne, Zhang, Yuemei, Yamada, Takatsugu, Wang, Max, Lu, Jiaqi, Jermendy, Agnes, Bee, Yong Mong, Bonner-Weir, Susan, Weir, Gordon C., Zhou, Qiao
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744133/
https://ncbi.nlm.nih.gov/pubmed/26693711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-015-3838-7
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